P26 Should we use intra-articular TNF-α inhibitor infliximab for resistant inflammatory mono- or oligo-arthritis?
نویسندگان
چکیده
منابع مشابه
Treatment of resistant rheumatoid arthritis by intra-articular infliximab injections: a pilot study.
R heumatoid arthritis (RA) is a chronic inflammatory disease which is characterised mainly by synovial inflammation and joint destruction, as well as extraarticular manifestations. Cytokines have a central role in the pathogenesis of this synovial inflammation. Tumour necrosis factor a (TNFa) is one of the dominant cytokines. Many studies have shown that TNFa is present in biologically signific...
متن کاملChronic Inflammatory Demyelinating Polyneuropathy Following Anti-TNF-α Therapy With Infliximab for Crohn's Disease.
We present a 29-year-old male with Crohn's disease who developed chronic inflammatory demyelinating polyneuropathy (CIDP) related to infliximab therapy. He developed lower extremity weakness and dysesthesia 3 weeks after a fourth infliximab dose. Laboratory examination revealed an elevated cerebrospinal fluid protein without pleocytosis. The patient initially responded to plasmapheresis therapy...
متن کاملThe Effect of Intra-Articular Injection of Two Anti TNF Drugs on Histopathology and Effect of Local Infusion of these Drugs on Blood Flow of Chronically Inflamed Joints in Rabbit
Background & Aims: The anti TNF drugs are new line treatment for articular inflammatory diseases which are used systemically, but due to expensiveness and some systemic adverse effects have limited usage. The aims of this study were to investigate the effect of intra-articular (local) injection of Etanercept and Infliximab as two anti TNF drugs on histopathology and also due to the important ro...
متن کامل[Intra-articular therapy with infliximab in psoriatic arthritis: efficacy and safety in refractory monoarthritis].
OBJECTIVE To evaluate efficacy and safety of intra-articular therapy (IA) with infliximab (IFX), in patients with psoriatic arthritis (PsA) and refractory monoarthritis. METHODS Four male and 1 female aged from 25 to 71 years and disease duration from 1 to 25 years, affected by PsA (CASPAR criteria) were observed . All patients were treated with immunomodulators (methotrexate, leflunomide, cy...
متن کاملResveratrol downregulates inflammatory pathway activated by lymphotoxin α (TNF-β) in articular chondrocytes: Comparison with TNF-α
While Lymphotoxin α (TNF-β), a product of lymphocytes, is known to play a pivotal role in inflammatory joint environment, resveratrol has been shown to possess anti-inflammatory and chondroprotective effects via activation of the histondeacetylase Sirt1. Whether TNF-β induction of inflammatory pathways in primary human chondrocytes (PCH) can be modulated by resveratrol, was investigated. Monola...
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ژورنال
عنوان ژورنال: Indian Journal of Rheumatology
سال: 2009
ISSN: 0973-3698
DOI: 10.1016/s0973-3698(09)60044-3